Clarksdale is a somewhat small city located in the state of Mississippi. With a population of 13,969 people and five associated neighborhoods, Clarksdale is the 26th largest community in Mississippi.

Telecommuters are a relatively large percentage of the workforce: 8.68% of people work from home. While this number may seem small overall, as a fraction of the total workforce it is high relative to the nation. These workers are often telecommuters who work in knowledge-based, white-collar professions. For example, Silicon Valley has large numbers of people who telecommute. Other at-home workers may be self-employed people who operate small businesses out of their homes.

The overall crime rate in Clarksdale is one of the lowest in the US. This makes it one of the safer places to live in the country in terms of crime.

Compared to the rest of the country, citizens of Clarksdale spend much less time in their cars: on average, their commute to work is only 17.46 minutes. This also means that noise and pollution levels in the city are less than they would otherwise be.

In terms of college education, Clarksdale is nearly on par with the US average for all cities of 21.84%: 20.99% of adults 25 and older in Clarksdale have a bachelor's degree or advanced degree.

The per capita income in Clarksdale in 2022 was $21,166, which is lower middle income relative to Mississippi, and low income relative to the rest of the US. This equates to an annual income of $84,664 for a family of four. However, Clarksdale contains both very wealthy and poor people as well. Clarksdale also has one of the higher rates of people living in poverty in the nation, with 40.70% of its population below the federal poverty line.

Clarksdale is a somewhat ethnically-diverse city. The people who call Clarksdale home describe themselves as belonging to a variety of racial and ethnic groups. The greatest number of Clarksdale residents report their race to be Black or African-American, followed by White. Important ancestries of people in Clarksdale include English, Italian, Irish, German, and Scottish.

The most common language spoken in Clarksdale is English. Other important languages spoken here include Spanish and Italian.