Murphysboro is a somewhat small city located in the state of Illinois. With a population of 6,963 people and four associated neighborhoods, Murphysboro is the 279th largest community in Illinois.

A relatively large number of people in Murphysboro telecommute to their jobs. Overall, about 8.23% of the workforce works from home. While this may seem like a small number, as a fraction of the total workforce it ranks among the highest in the country. These workers are often telecommuters who work in knowledge-based, white-collar professions. For example, Silicon Valley has large numbers of people who telecommute. Other at-home workers may be self-employed people who operate small businesses out of their homes.

As is often the case in a small city, Murphysboro doesn't have a public transportation system that people use for their commute.

In terms of college education, Murphysboro is nearly on par with the US average for all cities of 21.84%: 19.38% of adults 25 and older in Murphysboro have a bachelor's degree or advanced degree.

The per capita income in Murphysboro in 2022 was $28,303, which is low income relative to Illinois, and lower middle income relative to the rest of the US. This equates to an annual income of $113,212 for a family of four. However, Murphysboro contains both very wealthy and poor people as well.

Murphysboro is a very ethnically-diverse city. The people who call Murphysboro home describe themselves as belonging to a variety of racial and ethnic groups. The greatest number of Murphysboro residents report their race to be White, followed by Black or African-American. Murphysboro also has a sizeable Hispanic population (people of Hispanic origin can be of any race). People of Hispanic or Latino origin account for 11.32% of the city’s residents. Important ancestries of people in Murphysboro include German, Irish, English, French, and Scottish.

The most common language spoken in Murphysboro is English. Other important languages spoken here include Spanish and Italian.