Calexico is a medium-sized city located in the state of California. With a population of 38,249 people and ten associated neighborhoods, Calexico is the 216th largest community in California.

Telecommuters are a relatively large percentage of the workforce: 7.63% of people work from home. While this number may seem small overall, as a fraction of the total workforce it is high relative to the nation. These workers are often telecommuters who work in knowledge-based, white-collar professions. For example, Silicon Valley has large numbers of people who telecommute. Other at-home workers may be self-employed people who operate small businesses out of their homes.

In terms of college education, Calexico is nearly on par with the US average for all cities of 21.84%: 20.28% of adults 25 and older in Calexico have a bachelor's degree or advanced degree.

The per capita income in Calexico in 2022 was $19,676, which is low income relative to California and the nation. This equates to an annual income of $78,704 for a family of four. However, Calexico contains both very wealthy and poor people as well.

Calexico is an extremely ethnically-diverse city. The people who call Calexico home describe themselves as belonging to a variety of racial and ethnic groups. People of Hispanic or Latino origin are the most prevalent group in Calexico, accounting for 97.81% of the city’s residents (people of Hispanic or Latino origin can be of any race). The greatest number of Calexico residents report their race to be Asian, followed by White. Important ancestries of people in Calexico include Portuguese, Irish, Italian, German, and Armenian.

Foreign born people are also an important part of Calexico's cultural character, accounting for 43.55% of the city’s population.

The most common language spoken in Calexico is Spanish. Other important languages spoken here include English and Chinese.